HCP About Phages – Phyla Skincare

Use Of Phages In Acne Is A Natural, First-In-Class Approach, Bridging Gaps In Current Treatments

Bateriophages, or

phages, have been

studied for over a

century and are

considered safe.1, 2

Phages are natural

predators of bacteria and

are highly selective in

their targeting. Once their

host target is eliminated,

phages naturally

biodegrade.2

Studies link acne-free

skin to the abundance of

C. acnes phages and the

presence of acne lesions

is associated with fewer

phages.3

Phages bring the skin back to a healthy, acne-free state, by controlling the overgrowth of C. acnes. We call this ‘precise microbiome editing’.

PHYLA SUPPORTS A DIVERSE MICROBIOTA

A History of Phages

The widespread adoption of antibiotics contributed to

the decline in interest and broad awareness of phages.

However, the rise of antibiotic resistance has contributed to

a resurgence in the therapeutic applications of phages.

Research continues to demonstrate a correlation between lower skin microbiome diversity and inflammatory skin conditions including acne, psoriasis, and atopic dermatitis. We welcome you to explore some of the published literature.

PUBLICATIONS

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Barnard, 2016\ \ The balance of metagenomic elements shapes the skin microbiome in acne and health Golembo, 2022\ \ Development of a topical bacteriophage gel targeting cutibacterium acnes for acne prone skin and results of a phase 1 cosmetic randomized clinical trial Golembo, 2022\ \ Development of natural bacteriophages for skin care Lam, 2021\ \ Therapeutic effect of a newly isolated lytic bacteriophage against multi-drug-resistant cutibacterium acnes infection in mice Lin, 2021\ \ Development of bacteriophage cocktail targeting Staphylococcus aureus to treat atopic dermatitis Ly-Chatain, 2014\ \ The factors affecting effectiveness of treatment in phages therapy Natarelli, 2023\ \ Bacteriophages and the microbiome in dermatology: the role of the phageome and a potential therapeutic strategy

Many conventional acne treatments kill all bacteria, without the ability to target only the pathogenic C. acnes responsible for lesions, further disrupting the skin microbiota

Phages are a safe, natural treatment to change the microbiota for the better and without compromising the skin barrier.4

References: 1. Natarelli, N.; Gahoonia, N.; Sivamani, R.K. Bacteriophages and the Microbiome in Dermatology: The Role of the Phageome and a Potential Therapeutic Strategy. Int. J. Mol. Sci. 2023, 24, 2695. https://doi.org/ 10.3390/ijms24032695. 2. Ly-Chatain MH (2014) The factors affecting effectiveness of treatment in phages therapy. Front. Microbiol. 5:51. doi: 0.3389/fmicb.2014.00051. 3. Barnard, E. et al. The balance of metagenomic elements shapes the skin microbiome in acne and health. Sci. Rep. 6, 39491; doi: 10.1038/srep39491 (2016). 4. Golembo M, Puttagunta S, Rappo U, Weinstock E, Engelstein R, Gahali-Sass I, et al. Development of a topical bacteriophage gel targeting Cutibacterium acnes for acne prone skin and results of a phase 1 cosmetic randomized clinical trial. Skin Health Dis. 2022;2(2):e93. ttps://doi.org/10.102/ski2.93.

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