# Use Of Phages In Acne Is A Natural, First-In-Class Approach, Bridging Gaps In Current Treatments Bateriophages, or phages, have been studied for over a century and are considered safe.1, 2 Phages are natural predators of bacteria and are highly selective in their targeting. Once their host target is eliminated, phages naturally biodegrade.2 Studies link acne-free skin to the abundance of _C. acnes_ phages and the presence of acne lesions is associated with fewer phages.3 ### Phages bring the skin back to a healthy, acne-free state, by controlling the overgrowth of _C. acnes_. We call this ‘precise microbiome editing’. [PHYLA SUPPORTS A DIVERSE MICROBIOTA](/content/pages/hcp-results/index.html) ### A History of Phages The widespread adoption of antibiotics contributed to the decline in interest and broad awareness of phages. However, the rise of antibiotic resistance has contributed to a resurgence in the therapeutic applications of phages. Research continues to demonstrate a correlation between lower skin microbiome diversity and inflammatory skin conditions including acne, psoriasis, and atopic dermatitis. We welcome you to explore some of the published literature. - ### PUBLICATIONS Click to expandClick to close [Barnard, 2016\\ \\ The balance of metagenomic elements shapes the skin microbiome in acne and health](https://www.nature.com/articles/srep39491) [Golembo, 2022\\ \\ Development of a topical bacteriophage gel targeting cutibacterium acnes for acne prone skin and results of a phase 1 cosmetic randomized clinical trial](https://pubmed.ncbi.nlm.nih.gov/35677920/) [Golembo, 2022\\ \\ Development of natural bacteriophages for skin care](https://www.biomx.com/wp-content/uploads/2022/01/a11y-Acne-AAD-March2020.pdf) [Lam, 2021\\ \\ Therapeutic effect of a newly isolated lytic bacteriophage against multi-drug-resistant cutibacterium acnes infection in mice](https://pubmed.ncbi.nlm.nih.gov/34209998/) [Lin, 2021\\ \\ Development of bacteriophage cocktail targeting Staphylococcus aureus to treat atopic dermatitis](https://www.biomx.com/wp-content/uploads/2022/01/a11y-RAD-2021-Poster_June-2021F.pdf) [Ly-Chatain, 2014\\ \\ The factors affecting effectiveness of treatment in phages therapy](https://pubmed.ncbi.nlm.nih.gov/24600439/) [Natarelli, 2023\\ \\ Bacteriophages and the microbiome in dermatology: the role of the phageome and a potential therapeutic strategy](https://pubmed.ncbi.nlm.nih.gov/36769020/) ### Many conventional acne treatments kill all bacteria, without the ability to target only the pathogenic _C. acnes_ responsible for lesions, further disrupting the skin microbiota ### Phages are a safe, natural treatment to change the microbiota for the better and without compromising the skin barrier.4 References: 1. Natarelli, N.; Gahoonia, N.; Sivamani, R.K. Bacteriophages and the Microbiome in Dermatology: The Role of the Phageome and a Potential Therapeutic Strategy. Int. J. Mol. Sci. 2023, 24, 2695. https://doi.org/ 10.3390/ijms24032695. **2.** Ly-Chatain MH (2014) The factors affecting effectiveness of treatment in phages therapy. Front. Microbiol. 5:51. doi: 0.3389/fmicb.2014.00051. **3.** Barnard, E. et al. The balance of metagenomic elements shapes the skin microbiome in acne and health. Sci. Rep. 6, 39491; doi: 10.1038/srep39491 (2016). **4.** Golembo M, Puttagunta S, Rappo U, Weinstock E, Engelstein R, Gahali-Sass I, et al. Development of a topical bacteriophage gel targeting Cutibacterium acnes for acne prone skin and results of a phase 1 cosmetic randomized clinical trial. Skin Health Dis. 2022;2(2):e93. ttps://doi.org/10.102/ski2.93. © 2025 PHYLA. ALL RIGHTS RESERVED. Contact Us: [info@phitherapeutics.com](mailto:info@phitherapeutics.com) [PRIVACY](/content/pages/privacy-policy-1/index.html) / [TERMS](/content/pages/terms/index.html) shop.app # shop.app is blocked This page has been blocked by an extension - Try disabling your extensions. ERR\_BLOCKED\_BY\_CLIENT Reload This page has been blocked by an extension phyla.com # phyla.com is blocked This page has been blocked by an extension - Try disabling your extensions. ERR\_BLOCKED\_BY\_CLIENT Reload This page has been blocked by an extension phyla.com # phyla.com is blocked This page has been blocked by an extension - Try disabling your extensions. ERR\_BLOCKED\_BY\_CLIENT Reload This page has been blocked by an extension phyla.com # phyla.com is blocked This page has been blocked by an extension - Try disabling your extensions. ERR\_BLOCKED\_BY\_CLIENT Reload This page has been blocked by an extension phyla.com # phyla.com is blocked This page has been blocked by an extension - Try disabling your extensions. ERR\_BLOCKED\_BY\_CLIENT Reload This page has been blocked by an extension phyla.com # phyla.com is blocked This page has been blocked by an extension - Try disabling your extensions. ERR\_BLOCKED\_BY\_CLIENT Reload This page has been blocked by an extension Your cart is empty.